Trimethyl Orthoformate

1-bromo-3-chloropropane

Trimethyl Orthoformate

Trimethyl orthoformate, with the chemical formula (CH3O)3CH, is an organic compound commonly used as a reagent in organic synthesis. It appears as a colorless liquid with a pungent odor.

Applications:

  1. Acylation Reactions: Trimethyl orthoformate is used as a reagent in acylation reactions to introduce formyl groups into organic compounds.

  2. Protecting Group: It serves as a protecting group for alcohols in organic synthesis, preventing unwanted reactions at the hydroxyl group.

  3. Methylation Reactions: It is employed in methylation reactions, where it serves as a source of methyl groups.

  4. Intermediate: Trimethyl orthoformate is utilized as an intermediate in the pharmaceutical and agrochemical industries for the synthesis of various compounds.

Property Specification
Chemical Formula (CH3O)3CH
Molecular Weight 118.13 g/mol
Appearance Colorless liquid
Boiling Point 102-103°C
Melting Point -109°C
Density 0.946 g/cm3 at 20°C
Solubility Miscible with most organic solvents